Karel Allegaert Selected Research

Allopurinol (Remid)

3/2024	Correction: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).
1/2024	Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).
11/2022	Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates.
1/2022	Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.
1/2021	Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance.
1/2019	Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).

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Karel Allegaert Research Topics

Disease

27	Pain (Aches) 02/2024 - 06/2003
18	Birth Weight (Birth Weights) 05/2024 - 11/2004
15	Hypothermia 03/2024 - 03/2011
14	Asphyxia (Suffocation) 01/2023 - 01/2012
13	Body Weight (Weight, Body) 10/2020 - 01/2012
11	Pulmonary Hypertension 01/2023 - 01/2012
10	Sepsis (Septicemia) 02/2024 - 11/2014
10	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2024 - 01/2019
9	Critical Illness (Critically Ill) 11/2022 - 06/2008
8	Infections 01/2022 - 01/2012
8	Patent Ductus Arteriosus 10/2020 - 11/2004
7	Congenital Diaphragmatic Hernias 12/2023 - 01/2016
7	Bacterial Infections (Bacterial Infection) 12/2023 - 04/2014
7	Drug-Related Side Effects and Adverse Reactions 01/2023 - 06/2015
7	Hypertension (High Blood Pressure) 01/2023 - 02/2009
7	Retinopathy of Prematurity (Retrolental Fibroplasia) 12/2017 - 03/2003
6	Brain Diseases (Brain Disorder) 12/2023 - 01/2019
5	Neonatal Abstinence Syndrome 07/2022 - 11/2016
5	Fever (Fevers) 01/2020 - 03/2011
4	Brain Injuries (Brain Injury) 03/2024 - 01/2019
4	Acute Kidney Injury (Acute Renal Failure) 02/2024 - 01/2020
4	Inflammation (Inflammations) 12/2023 - 01/2016
4	Hypoxia (Hypoxemia) 01/2023 - 01/2012
4	COVID-19 12/2022 - 01/2021
4	Hemorrhage 01/2022 - 10/2011
4	Hyperoxia 02/2020 - 01/2016
4	Gastroesophageal Reflux (GERD) 01/2020 - 01/2017
3	Heart Failure 02/2024 - 01/2012
3	Bronchopulmonary Dysplasia 10/2023 - 01/2020
3	Hypotension (Low Blood Pressure) 02/2023 - 11/2018
3	Fetal Growth Retardation (Intrauterine Growth Retardation) 10/2022 - 12/2018
3	Lung Diseases (Lung Disease) 01/2022 - 10/2017
3	Procedural Pain 01/2020 - 09/2010
3	Wounds and Injuries (Trauma) 01/2020 - 01/2013
2	Premature Birth (Birth, Premature) 01/2023 - 02/2020
2	Necrotizing Enterocolitis 01/2023 - 04/2014
2	Pulmonary Arterial Hypertension 01/2023 - 01/2022
2	Common Cold 12/2022 - 11/2021
2	Reinfection 11/2022 - 01/2019
2	Hypersensitivity (Allergy) 05/2022 - 01/2022
2	Postoperative Pain 01/2022 - 06/2019
2	Diaphragmatic Hernia 11/2021 - 01/2016

Drug/Important Bio-Agent (IBA)

24	Acetaminophen (Paracetamol)FDA LinkGeneric 08/2023 - 09/2010
14	CreatinineIBA 05/2024 - 07/2012
11	Anti-Bacterial Agents (Antibiotics)IBA 12/2023 - 01/2013
11	Sildenafil Citrate (Viagra)FDA Link 01/2023 - 01/2016
11	Ibuprofen (Motrin)FDA LinkGeneric 10/2020 - 11/2004
10	Analgesics (Analgesic Drugs)IBA 02/2024 - 06/2003
9	Amikacin (A.M.K)FDA LinkGeneric 01/2021 - 03/2006
8	Biomarkers (Surrogate Marker)IBA 01/2024 - 11/2011
8	Opioid Analgesics (Opioids)IBA 07/2022 - 12/2015
7	Phenobarbital (Luminal)FDA Link 10/2022 - 01/2013
6	Allopurinol (Remid)FDA LinkGeneric 03/2024 - 01/2019
6	Morphine (MS Contin)FDA LinkGeneric 01/2023 - 01/2017
6	Propofol (Diprivan)FDA LinkGeneric 09/2022 - 01/2012
5	Oxygen (Dioxygen)IBA 01/2023 - 10/2011
5	nasIBA 07/2022 - 11/2016
5	Indicators and Reagents (Reagents)IBA 01/2020 - 07/2009
5	Vancomycin FDA LinkGeneric 10/2019 - 06/2007
4	Retinaldehyde (Retinal)IBA 12/2016 - 06/2012
4	Indomethacin (Indometacin)FDA LinkGeneric 01/2015 - 11/2004
3	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2023 - 06/2015
3	Amoxicillin (Wymox)FDA LinkGeneric 11/2023 - 01/2021
3	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 11/2022 - 01/2021
3	Cefazolin (Ancef)FDA LinkGeneric 11/2021 - 02/2009
3	Midazolam (Versed)FDA LinkGeneric 01/2021 - 01/2019
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 01/2019
3	Caffeine (No Doz)FDA LinkGeneric 07/2020 - 11/2014
3	EnzymesIBA 01/2020 - 01/2012
3	AminoglycosidesIBA 12/2017 - 04/2013
3	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 05/2012
3	Cyclooxygenase InhibitorsIBA 06/2013 - 01/2012
3	Tramadol (K315)FDA LinkGeneric 02/2012 - 06/2008
2	Hypnotics and Sedatives (Sedatives)IBA 02/2024 - 07/2009
2	Proteins (Proteins, Gene)FDA Link 01/2024 - 12/2022
2	Xanthine OxidaseIBA 01/2024 - 01/2022
2	treprostinil FDA Link 12/2023 - 10/2020
2	SodiumIBA 01/2023 - 01/2012
2	Fentanyl (Sublimaze)FDA LinkGeneric 01/2023 - 01/2022
2	TrypsinIBA 12/2022 - 11/2021
2	Oral SpraysIBA 12/2022 - 11/2021
2	Oxypurinol (Oxipurinol)IBA 11/2022 - 01/2022
2	XanthineIBA 11/2022 - 01/2022
2	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 11/2022 - 01/2019
2	SuspensionsIBA 11/2022 - 01/2021
2	Uric Acid (Urate)IBA 11/2022 - 01/2022
2	HypoxanthineIBA 11/2022 - 01/2022
2	Vitamin K FDA Link 11/2021 - 01/2018

Therapy/Procedure

17	Therapeutics 07/2023 - 09/2003
12	Induced Hypothermia 01/2024 - 12/2017
8	Analgesia 02/2024 - 04/2005
7	Drug Therapy (Chemotherapy) 04/2024 - 10/2015
5	Artificial Respiration (Mechanical Ventilation) 10/2023 - 01/2019
5	Extracorporeal Membrane Oxygenation 11/2022 - 04/2018
3	Neonatal Intensive Care 01/2024 - 01/2020
3	Length of Stay 01/2021 - 01/2019
2	Pain Management 01/2023 - 07/2016
2	Aftercare (After-Treatment) 11/2022 - 01/2019
2	Critical Care (Surgical Intensive Care) 09/2021 - 12/2016
2	Precision Medicine 01/2021 - 01/2020